The Albino Deletions

THE ALBINO DELETIONS

Albino deletions define four functional intervals

The deletions pictured above cause developmental defects in homozygotes.

The mesoderm development (mesd) functional interval is defined by proximal Ai3 and E deletion breakpoints; Ai deletion homozygotes do not form mesoderm and die in utero.
The neuroendocrine survival (neur) functional region is located between the proximal E breakpoints; c^112Khomozygous embryos have hypothalamus defects not seen in c^3H mutants.
The cardiac neural crest (cardiac) region is located between the Ai2 and c^112Kdistal breakpoints; c^112K/ c^3H double heterozygotes have aberrant cardiac and thymic development.

We hypothesize that the Ai1 and Ai2 deletions uncover a fourth functional interval.