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Interior Design Element

Faculty

Robert S. Haltiwanger, Ph.D.
Professor
Department of Biochemistry and Cell Biology

Recent Publications
  1. Haltiwanger, R.S. (2009) Fucose is on the TRAIL of Colon Cancer. Gastroenterology IN PRESS.
  2. Haltiwanger, R.S. (2008) Unsweetened Notch leads to myeloproliferation. Blood 112, 214-215.
  3. Luther, K.B., Schindelin, H., and Haltiwanger. (2009) Structural and mechanistic insights into Lunatic Fringe from a kinetic analysis of enzyme mutants. J. Biol. Chem. 284, 3294-3305.
  4. Bakker, H., Oka, T., Ashikov, A., Yadav, A., Berger, M., Rana, N.A., Bai, X., Jigami, Y., Haltiwanger, R.S., Esko, J.D., Gerardy-Schahn, R. (2009) Functional UDP-xylose transport across the ER/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose synthase. J. Biol. Chem. 284, 2576-2583.
  5. Luther, K.B. and Haltiwanger, R.S. (2008) Role of unusual O-glycans in intercellular signaling. International Journal of Biochemistry and Cell Biology 41, 1011-1024.
  6. Ishikawa, H.O., Takeuchi, H., Haltiwanger, R.S., and Irvine, K.D. (2008) Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains. Science, 321, 401-404.
  7. Acar, M.*, Jafar-Nejad, H.*, Takeuchi, H.*, Rajan, A., Ibrani, D., Rana, N.A., Pan, H., Haltiwanger, R.S., and Bellen, H.J. (2008) Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling. Cell 132, 247-58.
  8. Xu, A., Haines, N., Dlugosz, M., Rana, N.A., Takeuchi, H., Haltiwanger, R.S., and Irvine, K.D. (2007) In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe.  J. Biol. Chem. 282, 35153-62.
  9. Rampal, R., Luther, K., and Haltiwanger, R.S.  (2007) Notch Signaling in Normal and Disease States:  Possible Therapies Related to Glycosylation.  Current Molecular Medicine 7, 427-445.
  10. Shi, S., Ge, C., Luo, Y., Hou, X., Haltiwanger, R.S. and Stanley, P. (2007) The threonine that carries fucose, but not fucose, is required for Cripto to facilitate Nodal signaling.  J. Biol. Chem. 282, 20133-20141.
  11. Wang, L.W., Dlugosz, M., Somerville, R.P., Raed, M., Haltiwanger, R.S., and Apte, S.S. (2007) O-Fucosylation of thrombospondin type 1 repeats in ADAMTS like-1/punctin-1 regulates secretion: Implications for the ADAMTS superfamily. J. Biol. Chem. 282, 17024-17031. (Co-Paper of the week)
  12. Ricketts, L.M., Dlugosz, M., Luther, K.B., Haltiwanger, R.S., and Majerus, E.M. (2007) O-Fucosylation is Required for ADAMTS13 Secretion.  J. Biol. Chem. 282, 17014-17023. (Co-Paper of the Week)
  13. Nita-Lazar, A. and Haltiwanger, R.S. (2006) Methods for analysis of O-linked modifications on epidermal growth factor-like and thrombospondin type 1 repeats.  Meth. Enzymol. 417, 93-111.
  14. Kozma, K., Keusch, J.J., Hegemann, B., Luther, K.B., Klein, D., Hess, D., Haltiwanger, R.S., and Hofsteenge, J. (2006) Identification and characterization of a ß1,3-glucosyltransferase that synthesizes the Glc-ß1,3-Fuc disaccharide on thrombospondin type 1 repeats.  J. Biol. Chem. 281, 36742-36751.
  15. Loriol, C., Dupuy, F., Rampal., R., Dlugosz, M.A., Haltiwanger, R.S., Maftah, A., Germot, A. (2006) Molecular evolution of protein O-fucosyltransferase genes and splice variants.  Glycobiology 16, 736-747.
  16. Luo, Y., Koles, K., Vorndam, W., Haltiwanger, R.S., and Panin, V.M. (2006) Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats. J. Biol. Chem. 281, 9393-9399.
  17. Luo, Y., Nita-Lazar, A., and Haltiwanger, R.S. (2006) Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats. J. Biol. Chem. 281, 9385-9392.
  18. Rampal, R., Li, A.S.Y., Moloney, M.J., Georgiou, S.A., Luther, K.B., Nita-Lazar, A., and Haltiwanger, R.S. (2005) Lunatic fringe, Manic fringe, and Radical fringe recognize similar specificity determinants in O-fucosylated EGF repeats. J. Biol. Chem. 280,  42454-42463.
  19. Rampal, R., Arboleda-Velasquez,  J.F., Nita-Lazar, A., Kosik, K.S., and Haltiwanger, R.S. (2005) Highly Conserved O-fucose sites have distinct effects on Notch1 function.  J. Biol. Chem.  280, 32133-32140.
  20. Arboleda-Velasquez,  J.F., Rampal, R.,  Fung, E.,  Darland,  D.C.,  Liu,  M.,  Martinez,  M.C.,  Donahue,  C.P.,  Navarro-Gonzalez,  M.F.,  Libby, P.,  D'Amore, P.A.,  Aikawa,  M., Haltiwanger,  R.S., Kosik, K.S. (2005) CADASIL mutations impair Notch3 glycosylation by Fringe. Hum. Mol. Genet.14, 1631-1639.
  21. Luo, Y. and Haltiwanger, R.S. (2005) O-fucosylation of Notch occurs in the endoplasmic reticulum. J. Biol. Chem. 280,11289-11294.
  22. Haltiwanger, R.S. and Lowe, J.B. (2004) Role of Glycosylation in Development. Annu. Rev. Biochem. 73, 491-537.
  23. Sturla, L., Rampal, R., Haltiwanger, R.S., Fruscione, F., Etzioni, A. and Tonetti, M. (2003) Differential terminal fucosylation of N-linked glycans versus protein O-fucosylation inLeukocyte adhesion deficiency type II (CDG IIc). J. Biol. Chem.278, 26727-26733.
  24. Shao, L., Moloney, D.J., and Haltiwanger, R.S. (2003) Fringe modifies O-fucose on mouse Notch1 at EGF repeats within the ligand-binding site and the Abruptex region. J. Biol. Chem. 278, 7775-7782.
  25.  Haltiwanger, R.S. (2002) Regulation of signal transduction pathways in development by glycosylation. Current Opin. Struc. Biol. 12, 593-598.
  26. Haltiwanger, R.S. and Stanley, P.S. (2002) Modulation of receptor signaling by glycosylation: Fringe is an O-fucose-ß1,3-N-acetylglucosaminyltransferase. Biochem. Biophys. Acta. 1573, 328-335.
  27. Shao, L., Luo, Y., Moloney, D.J. and Haltiwanger, R.S. (2002) O-Glycosylation of EGF Repeats: Identification and Initial Characterization of a UDP-Glucose: Protein O-Glucosyltransferase. Glycobiology 12, 763-770.
  28. Panin, V.M., Shao, L., Lei, L., Moloney, D.J., Irvine, K.D. and Haltiwanger, R.S. Notch ligands are substrates for EGF protein O-fucosyltransferase and Fringe. (2002) J.Biol. Chem.277, 29945-29952.
  29. Yan, Y.-T., Liu, J.-J., Luo, Y., E, C., Haltiwanger, R.S., Abate-Shen, C. and Shen, M.M. (2002) Dual roles of Cripto as a ligand and co-receptor in the Nodal signaling pathway. Mol. Cell. Biol. 22, 4439-4449.
  30. Wang, Y., Shao, L., Shi, S., Harris, R.J., Spellman, M.W., Stanley, P. and Haltiwanger, R.S. (2001) Modification of Epidermal Growth Factor-Like Repeats with O-Fucose: Molecular Cloning and Expression of a Novel GDP-Fucose: Polypeptide O-Fucosyltransferase. J. Biol. Chem. 276, 40338-40345.
  31. Haltiwanger, R.S. (2001) Fringe: A glycosyltransferase that modulates Notch signaling. TIGG 13, 157-165.
  32. Moloney, D.J., Panin, V.M., Johnston, S.J., Chen, J., Shao, L., Wilson, R., Wang, Y., Stanley, P., Irvine, K.D., Haltiwanger, R.S. and Vogt, T.F. (2000) Fringe is a Glycosyltransferase that Modifies Notch. Nature 406, 369-375.
  33. Moloney, D., Shair, L.H., Lu, F., Xia, J., Locke, R., Matta, K.L. and Haltiwanger, R.S. (2000) Mammalian Notch 1 is modified with two unusual forms of O-linked glycosylation found on Epidermal Growth Factor-like modules. J. Biol. Chem. 275, 9604-9611.

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