Previous Seed Grant Winners
Where are they now?
In 2002, Miriam Rafailovich of the Department of Materials Science and Engineering was awarded a seed grant for her proposal, "Which Comes First, the Eggshell or its Genes? Mimicking Biomineralization with Artificial Protein Networks."
The seed grant has enabled Dr. Rafailovich and students to jump start a very successful collaboration with BNL on biomineralization. The research was presented at the Materials Research Society meeting and it won first prize in the poster awards.
The team is now in the process of submitting
a paper to Proceedings of the National Academy of Science on this work, the
abstract follows:
Biomineralization is the process by which living organisms build inorganic mineral-based
structures. This process has been of vital interest for over a century, since
nature is known to produce mineral architectures, which exhibit superior mechanical
strength and other specialized properties. Understanding and mimicking this
process is critical to “biomimetic” materials science for inorganic-organic
hybrid materials (bio-ceramics), low temperature materials for electronics and
semiconductor applications and medical engineering of bone, teeth and cartilage.
A large body of literature already exists describing the process, but even the
most recent reviews emphasize on the diversity of biominerals than the shared
underlying mechanisms. Yet in order to understand the fundamental processes
leading to biomineralization, we must first focus on the phenomena that many
systems have in common. Therefore, in this paper we chose to focus on the very
early stages, which we feel may initiate the process in most systems.
Biominerals with highly intricate and organized structures are formed under
highly regulated biological environments. Based on these environments, biomineralization
can be classified as an intracellular, intercellular or extra-cellular process.
Here we will focus on the extracellular process only. The extracellular process
occurs outside the cell-wall on a matrix of organic macromolecules or proteins,
known as the extra cellular matrix (ECM), which controls numerous cell functions
and also determines the rate of formation and the orientation of the inorganic
crystals. Physiological extracellular mineralization in humans is mostly restricted
to bones, teeth and the hypertrophic zones of growth plate cartilage. In other
organisms, it can range from egg shells to nacre and other shell fish structures
. Pathological instances of ECM mediated calcification are also common. For
example, in humans calcification of vascular tissue is a common complication
found in diseases like aging, atherosclerosis, and diabetes . Similarly, aviary
diseases like mycoplasmosis affects the formation of egg shell layers resulting
in reduced egg production. Finding a remedy for these problems requires us to
first obtain a fundamental understanding of the mineralization process at the
molecular level.