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Organic Chemistry

Organic chemistry research at Stony Brook covers synthetic and physical organic chemistry, organometallics, catalysis, bioorganic chemistry, medicinal chemistry, and materials chemistry. Our wide range of research projects includes development of new and efficient synthetic methods, including organometallic reagents, catalysts; syntheses of natural and unnatural compounds of special interest in medicinal chemistry or materials chemistry; elucidation of enzyme reaction mechanisms, protein-protein, structure-activity relationship of pharmaceutical agents such as anticancer agents, various enzyme inhibitors, and receptor antagonists; preparation of organic solids with designed supramolecular geometry; and the use of organic models to explore polymer structures and properties.

Underpinning it all is a strong commitment to organic synthesis, which is what gives organic chemistry its unique power as a creative science.

		Dale Drueckhammer	Professor. Computer-based design and synthesis of receptors and sensors for biomolecules. Design and synthesis of enzyme inhibitors. Enzyme reaction mechanisms.
		Frank Fowler	Professor. Synthetic chemistry.
		Nancy S. Goroff	Associate Professor. Non-natural organic compounds and their properties; organic materials.
		Frank Johnson	Professor. Synthesis of viral enzyme inhibitors. Chemical aspects of genetic toxicology. New organo-alkali synthetic chemistry.
		Joseph Lauher	Professor. Structural chemistry and X-ray crystallography, supramolecular chemistry and crystal engineering, hydrogen bonding, topochemical polymerizations, conjugated polymers. molecular graphics.
		Iwao Ojima	Distinguished Professor. Design, synthesis, and structure-activity relationships of medicinally-active compounds, especially anticancer agents. Development of new synthetic methods based on asymmetric synthesis, homogeneous catalysis and organometallic chemistry.
		Kathlyn Parker	Professor. Synthetic chemistry.
		Nicole Sampson	Professor. Bioorganic chemistry and mechanistic enzymology. Protein-membrane interactions, their structure and function. Role of ADAM proteins in mammalian fertilization
		Peter Tonge	Professor. Biological chemistry and enzymology. Quantitating substrate strain in enzyme-catalyzed reactions using vibrational and NMR spectroscopies. Rational drug design. Pathogenesis of Mycobacterium tuberculosis. Structure-function studies of fluorescent proteins.


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