2007
1. Lu, H. and Tonge, P.J. (2007) Acc. Chem. Res. accepted. Inhibitors of FabI, an Enzyme Drug Target in the Bacterial Fatty Acid Biosynthesis Pathway.
2. Stelling, A., Ronayne, K. L., Nappa, J., Tonge, P.J. and Meech, S.R. (2007) J. Am. Chem. Soc. accepted. Ultrafast Structural Dynamics in BLUF Domains: Transient Infrared Spectroscopy of AppA and its Mutants.
3. Tasdemir, D.; Topaloglu, B.; Perozzo, R.; Brun, R.; O'Neill, R.; Carballeira, N. M.; Zhang, X.; Tonge, P. J.; Linden, A.; Ruedi, P., Bioorg. Med. Chem. (2007) 15, 6834-45. Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli. Medline
4. Boyne, M. E.; Sullivan, T. J.; Amende, C. W.; Lu, H.; Gruppo, V.; Heaslip, D.; Amin, A. G.; Chatterjee, D.; Lenaerts, A.; Tonge, P. J.; Slayden, R. A., Antimicrob. Agents Chemother. (2007) 51, 3562-7. Targeting Fatty Acid Biosynthesis for the Development of Novel Chemotherapeutics against Mycobacterium tuberculosis: Evaluation of A-Ring-Modified Diphenyl Ethers as High-Affinity Inha Inhibitors. Medline
5. Kruh, N. A.; Rawat, R.; Ruzsicska, B. P.; Tonge, P. J., Protein Sci. (2007) 16, 1617-27. Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis. Medline
6. Bonnac, L.; Gao, G. Y.; Chena, L.; Felczaka, K.; Bennetta, E. M.; Xub, H.; Kim, T. S.; Liu, N.; Oh, H. W.; Tonge, P. J.; Pankiewicz, K. W., Bioorg. Med. Chem. Lett. (2007) 17, 4588-91. Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis. Medline
7. Bell, A. F.; Stratton, C. F.; Zhang, X.; Novichenok, P.; Jaye, A. A.; Nair, P. A.; Parikh, S.; Rawat, R.; Tonge, P. J., J. Am. Chem. Soc. (2007) 129, 6425-31. Evidence from Raman spectroscopy that InhA, the mycobacterial enoyl reductase, modulates the conformation of the NADH cofactor to promote catalysis. Medline
8. Tonge, P.J., Kisker, C., and Slayden, R.A. (2006) Current Topics in Medicinal Chemistry, 7, 489-98 . Development of Modern InhA Inhibitors to Combat Drug Resistant Strains of Mycobacterium tuberculosis . Medline
9. Huang, Q., Tonge, P.J. Slayden, R.A., Kirikae, T. and Ojima, I. (2006) Current Topics in Medicinal Chemistry, 7, 527-43 . FtsZ, a Novel Target for Anti-TB Drug Discovery. Medline
10. Kolappan, S. Zwahlen, J., Zhou, R., Truglio, J., Tonge, P.J. and Kisker, C. (2007) Biochemistry 46, 946-53. . Lysine 190 is the Catalytic Base in MenF, the Menaquinone-Specific Isochorismate Synthase from E. Coli: Implications for an Enzyme Family. Medline
11. Zwahlen, J., Kolappan, S., Zhou, R., Kisker, C. and Tonge, P.J. (2007) Biochemistry 46, 954-64 . Structure and Mechanism of MbtI, the Salicylate Synthase from Mycobacterium tuberculosis. Medline
2006
12. Kondo, M.; Nappa, J.; Ronayne, K. L.; Stelling, A. L.; Tonge, P. J.; Meech, S. R. (2006) J. Phys. Chem. B. 110, 20107-10 . Ultrafast Vibrational Spectroscopy of the Flavin Chromophore. Medline
13. Stoner-Ma, D.; Melief, E. H.; Nappa, J.; Ronayne, K. L.; Tonge, P. J.; Meech, S. R. (2006) J. Phys. Chem. B. 110, 22009-18 . Proton Relay Reaction in Green Fluorescent Protein (GFP): Polarization-Resolved Ultrafast Vibrational Spectroscopy of Isotopically Edited GFP. Medline
14. Rafi, S., Novichenok, P., Kolappan, S., Zhang, X., Stratton, C.F., Rawat, R., Kisker, C., Simmerling, C. and Tonge, P.J. (2006) J. Biol. Chem. 281, 39285-93 . Structure of Acyl Carrier Protein Bound to FabI, the FASII Enoyl Reductase from Escherichia coli. Medline
15. Huang, Q., Kirikae, F., Kirikiae, T., Pepe, A., Amina, A., Respicio, L., Slayden, R.A., Tonge, P.J. and Ojima, I. (2006) J. Med. Chem. 49, 463-6. Targeting FtsZ for Antituberculosis Drug Discovery: Noncytotoxic Taxanes as Novel Antituberculosis Agents. Medline
16. Jaye, A.A., Stoner-Ma, D., Matousek, P., Towrie, M., Tonge, P.J. and Meech, S.R. (2006) Photochem. Photobiol. 82, 373-9. Time Resolved Emission Spectra of the Green Fluorescent Protein. Medline
17. Sullivan, T.J., Truglio, J.J., Boyne, M.E., Novichenok, P., Zhang, X., Stratton, C.F., Li, H-J., Kaur, T., Amin, A., Johnson, F., Slayden, R.A., Kisker, C. and Tonge, P.J. (2006) ACS Chemical Biology, 1, 43-53. High Affinity InhA Inhibitors With Activity Against Drug Resistant Strains of Mycobacterium Tuberculosis. Medline
18. Callahan, B.P., Bell, A.F., Tonge, P.J. and Wolfenden, R. (2006) Bioorganic Chemistry, 34, 59-65. A Raman-active competitive inhibitor of OMP decarboxylase. Medline
19. Rafi, S., Cui, G., Song, K., Tonge, P.J. and Simmerling, C. (2006) J. Med. Chem. 49, 4574-80. Predicting the Binding Affinity of Triclosan and Three Triclosan Analogs for FabI, the E. Coli Enoyl Reductase, Using MM-PBSA Calculations. Medline
2005
20. Stoner-Ma, D., Jaye, A.A., Matousek, P., Towrie, M., Meech, S.R. and Tonge, P.J. (2005) J. Am. Chem. Soc. 127, 2864-5. Observation of Excited State Proton Transfer in Green Fluorescent Protein Using Ultrafast Vibrational Spectroscopy. Medline
21. Wu, J., Bell, A.F. and Tonge, P.J. (2005) J. Am. Chem. Soc. 127, 8424-32. Ring Current Effects in the Active Site of Medium-Chain Acyl-CoA Dehydrogenase Revealed by NMR Spectroscopy. Medline
22. Doll, C., Bell, A.F., Power, N., Tonge, P.J. and Tipton, P.A. (2005) Biochemistry 44, 11440-6. Procatalytic Ligand Strain. Ionization and Perturbation of 8-Nitroxanthine at the Urate Oxidase Active Site. Medline
23. Carlisle-Moore, L., Gordon, C.R., Machutta, C.A., Miller, W.T. and Tonge, P.J. (2005) J. Biol. Chem. 280, 42612-8. Substrate recognition by the human fatty acid synthase. Medline
2004
24. Vengris, m., van Stokkum, I.H.M., He, X., Bell, A.F., Tonge, P.J., van Grondelle, R. and Larsen, D.S. (2004) J. Phys. Chem. A. 108, 4587-4598. Ultrafast Excited and Ground-State Dynamics of the Green Fluorescent Protein Chromophore in Solution.
25. Sivaraman, S., Sullivan, T., Johnson, F., Novichenok, P., Cui, G., Simmerling, C. and Tonge, P.J. (2004) J. Med. Chem., 47, 509-518. Inhibition of the Bacterial Enoyl Reductase FabI by Triclosan: A Structure-Reactivity Analysis of FabI Inhibition by Triclosan Analogs. Medline
2003
26. Rawat, R., Whitty, A. and Tonge, P.J. (2003) Proc. Natl. Acad. Sci. U.S.A., 100, 13881-13886. The Isoniazid-NAD Adduct is a Slow, Tight-Binding Inhibitor of InhA, the Mycobacterium Tuberculosis Enoyl Reductase; Adduct Affinity and Drug Resistance. Medline
27. Boye, S., Nielsen, S.B., Krogh, H., Nielsen, I.B., Pedersen, U.V., Bell, A.F., He X, Tonge, P.J.and Andersen, L.H. (2003) Phys. Chem. Chem. Phys., 5, 3021-3026. Gas-Phase Absorption Properties of DsRed Model Chromophores
28. Wu,J., Bell, A. F., Luo, L., Stephens, A.W., Stankovich, M. T. and Tonge,P.J. (2003) Biochemistry, 42, 11846-11856. Probing Hydrogen Bonding Interactions in the Active Site of Medium-Chain Acyl-CoA Dehydrogenase using Raman Spectroscopy. Medline
29. Truglio, J.J., Theis, K., Feng, Y., Gajda, R., Machutta, C., Tonge, P.J. and Kisker, C. (2003) J. Biol. Chem., 278, 42352-42360. Crystal Structure of Mycobacterium tuberculosis MenB, a Key Enzyme in Vitamin K2 Biosynthesis. Medline
30. Sivaraman, S., Hedstrom, L. and Tonge, P.J.+ (2003) Biochemistry, 42, 4406-13. Structure-Activity Studies of the Inhibition of FabI, the Enoyl Reductase from Escherichia coli, by Triclosan: Kinetic Analysis of Mutant FabIs. Medline
31. Bell, A.F., Stoner-Ma, D., Wachter, R.M. and Tonge, P.J.+ (2003) J. Am. Chem. Soc. 125, 6919-6926. Light Driven Decarboxylation of Wild-type Green Fluorescent Protein. Medline
32. He, X., Bell, A.F. and Tonge, P.J.+ (2003) FEBS Lett. 549, 35-38. Ground state isomerization of a model green fluorescent protein chromophore. Medline.
33. Boye, S., Krogh, H., Nielsen, S.B., Pedersen, S.U., Pedersen, U.V., Andersen, L.H.+, Bell, A.F., He, X. and Tonge, P.J. (2003) Phys. Rev. Lett. 90, 118103. Vibrationally resolved photoabsorption spectroscopy of red fluorescent protein chromophore anions. Medline.
2002
34. ell, A.F., Feng, Y., Hofstein, H.A., Parikh, S., Wu, J., Rudolph, M.J., Kisker, C., Whitty, A. and Tonge, P.J. (2002) Chemistry & Biology, 9, 1247-1255. Stereoselectivity of Enoyl-CoA Hydratase Results from Preferential Activation of One of Two Bound Substrate Conformers. Medline
35. Feng, Y., Hofstein, H.A., Zwahlen, J. and Tonge, P.J. (2002) Biochemistry,41, 12883-90. Effect of Mutagenesis on the Stereochemistry of Enoyl-CoA Hydratase. Medline
36. He, X., Bell, A.F. and Tonge, P.J. (2002) Organic Letters, 4, 1523-1526. Synthesis and Spectroscopic Studies of Model Red Fluorescent Protein Chromophores. Medline.
37. He, X., Bell, A.F. and Tonge, P.J. (2002) J. Phys. Chem ., B106, 6056-6066. Isotopic Labeling and Normal Mode Analysis of a Model Green Fluorescent Protein Chromophore.
2001
38. Bell, A.F., Wu, J., Feng, Y. and Tonge, P.J. (2001) Biochemistry, 40, 1725-1733. Involvement of G141 in substrate activation by enoyl-CoA hydratase. Medline.
39. Dai, M., Feng, Y. and Tonge, P.J. (2001) J. Am. Chem. Soc., 123, 506-507. Synthesis of crotonyl-oxyCoA: A mechanistic probe of the reaction catalyzed by enoyl-CoA hydratase. Medline.
40. Bell, A.F., He, X., Ridge, J.P., Hanson, G.R., McEwan, A.G. and Tonge, P.J. (2001) Biochemistry, 40, 440-448. Active site heterogeneity in DMSO Reductase from Rhodobacter capsulatus revealed by Raman spectroscopy. Medline
2000
41. Pellett, J.D., Sabaj, K.M., Stephens, A.W., Bell, A.F., Wu, J., Tonge, P.J. and Stankovich, M.T. (2000) Biochemistry, 39, 13982-13992. Medium-Chain Acyl-Coenzyme A Dehydrogenase Bound to a Product Analogue, Hexadienoyl-Coenzyme A: Effects on Reduction Potential, pKa, and Polarization. Medline.
42. Gawlita, E., Lantz, M., Paneth, P., Bell, A.F., Tonge, P.J. and Anderson, V.E. (2000) J. Am. Chem. Soc., 122, 11660-11669. H-Bonding in Alcohols Is Reflected in the C-H Bond Strength: Variation of C-D Vibrational Frequency and Fractionation Factor
43. Parikh, S.L., Xiao, G. and Tonge, P.J. (2000) Biochemistry, 39, 7645-7650. Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid. Medline.
44. Wu, W., Feng, Y., He, X., Hofstein, H.S., Raleigh, D.P. and Tonge, P.J. (2000) J. Am. Chem. Soc. 122, 3987-3994. Stereospecificity of the reaction catalyzed by enoyl-CoA hydratase.
45. Bell, A.F., Xiang, H., Wachter, R.M. and Tonge, P.J. (2000) Biochemistry, 39, 4423-4431. Probing the ground state structure of the green fluorescent protein chromophore using Raman spectroscopy. Medline.
46. Tonge, P.J. (2000) Nat. Struct. Biol., 7, 94-96. Another brick in the wall. Medline.
47. Rudik, I., Bell, A.F., Tonge, P.J. and Thorpe, C. (2000) Biochemistry, 39, 92-101. 4-Hydroxycinnamoyl-CoA: An ionizable probe of the active site of acyl-CoA dehydrogenase. Medline.
1999
48. Stankovich, M.T., Sabaj, K.M. and Tonge, P.J. (1999) Arch. Biochem. Biophys., 370, 16-21. Structure/function of medium chain acyl-CoA dehydrogenase: The importance of substrate polarization.
49. Parikh, S., Moynihan, D.P., Xiao, G. and Tonge, P.J. (1999) Biochemistry, 38, 13623-13634. Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium Tuberculosis. Medline.
50. Hofstein, H.S., Feng, Y., Anderson, V.E. and Tonge, P.J. (1999) Biochemistry, 38, 9508-9516. Role of glutamate 144 and glutamate 164 in the catalytic mechanism of enoyl-CoA hydratase. Medline.
51. Stewart, M., Parikh, S., Xiao, G., Tonge, P.J. and Kisker, C. (1999) J. Mol. Biol.,290, 859-865. Structural basis for the mechanism of action of triclosan. Medline.
1998
52. Wu, W-J., Tonge, P.J. and Raleigh, D.P. (1998) J. Am. Chem. Soc., 120, 9988-9994. Stereospecific 1H and 13C NMR assignments of crotonyl-coenzyme A and hexadienoyl-coenzyme A: conformational analysis and comparison with protein:CoA complexes.
1997
53. Tonge, P.J., Carey, P.R. and Fausto, R . (1997) J. Chem. Soc. Faraday Trans., 93, 3619-3625. Molecular structure of S-ethyl thioacrylate. Combined vibrational spectroscopic and ab initio SCF-MO study.
54. Clarkson, J., Tonge, P.J., Taylor, K.L., Dunaway-Mariano, D. and Carey, P.R. (1997) Biochemistry, 36, 10192-10199. A Raman study of the polarizing forces promoting catalysis in 4-chlorobenzoate-CoA dehalogenase.
55. Wu, W-J., Anderson, V.E., Raleigh, D.P. and Tonge, P.J. (1997) Biochemistry, 36, 2211-2220. Structure of hexadienoyl-CoA bound to enoyl-CoA hydratase determined by transferred NOE measurements: mechanistic predictions based on the X-ray structure of 4-chlorobenzoyl-CoA dehalogenase. Medline.
1996
56. P opov, S., Dubrovsky, L., Lee, M-A., Pennathur, S., Haffer, O., Al-Abed, Y., Tonge, P.J., Ulrich, P., Rexach, M., Blobel, G., Cerami, A.C. and Bukrinsky, M. (1996) Proc. Natl. Acad. Sci. USA, 93, 11859-11864. Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation
57. Doran, J.D., Tonge, P.J., Mort, J.S. and Carey, P.R. (1996) Biochemistry, 35, 12487-12494. Deacylation and reacylation for a series of acyl cysteine proteases, including acyl groups derived from novel chromophoric substrates.
58. Tonge, P.J., Fausto, R. and Carey, P.R. (1996) J. Mol. Struct., 379, 135-142. FTIR studies of hydrogen bonding between a ,b -unsaturated esters and alcohols.
59. Moore A.N.J, Vakos H, Neville T.A.M, Tonge P.J., Arya P, Burton G.W. (1996) Biotechnology Techniques, 10, 523-528. A quick method for purifying bile salt-activated lipases.
1995
60. Tonge, P.J., Anderson, V.E., Fausto, R., Kim, M., Pusztai-Carey, M. and Carey, P.R. (1995) Biospectroscopy, 1, 387-394. Localized electron polarization in a substrate analog binding to the active site of enoyl-CoA hydratase: Raman spectroscopic and conformational analyses of rotamers of hexadienoyl thiolesters.
61. Doran, J.D., Tonge, P.J., Carey, P.R. and Arya, P. (1995) Bioorganic and Medicinal Chemistry Letters, 5, 2381-2384. Synthesis of chromophoric dipeptides as substrates for papain.
62. Taylor, K.L., Liu, R.Q., Liang, P.H., Price, J., Dunaway-Mariano, D., Tonge, P.J., Clarkson, J. and Carey, P.R. (1995) Biochemistry, 34, 13881-13888. Evidence for electrophilic catalysis in the 4-chlorobenzoyl-CoA dehalogenase reaction: UV, Raman and 13C-NMR spectral studies of dehalogenase complexes of benzoyl-CoA adducts.
63. Carey, P.R. and Tonge, P.J. (1995) Acc. Chem. Res., 28, 8-13. Unlocking the secrets of enzyme power using Raman spectroscopy.
1994
64. Fausto, R., Tonge, P.J. and Carey, P.R. (1994) J. Chem. Soc. Faraday Trans., 90, 3491-3503. Molecular structures of cis- and trans-S-ethyl thiocrotonate.
65. D'Ordine, R.L., Bahnson, B.J., Tonge, P.J. and Anderson, V.E. (1994) Biochemistry, 33, 14733-14742. Enoyl-CoA hydratase catalyzed exchange of the a -protons of CoA thiolesters: A model for an enolized intermediate in the enzyme catalyzed elimination?
66. D'Ordine, R.L., Tonge, P.J., Carey, P.R. and Anderson, V.E. (1994) Biochemistry, 33, 12635-12643. Electronic rearrangement induced by substrate analog binding to the enoyl-CoA hydratase active site: Evidence for substrate activation.
67. Doran, J.D., Tonge, P.J., Kim, M. and Carey, P.R. (1994) Photochemistry and Photobiology, 60, 432-434. Facile characterization of the spectra of cis and trans photoisomers in a mixture of acyl-enzymes by raman difference spectroscopy.
68. Fausto, R., Martins, A.G., Teixeira-Dias, J.J.C., Tonge, P.J. and Carey, P.R. (1994) J. Phys. Chem. 98, 3592-3596. Rotational isomerism in CH3CH2C(=S)SR (R=CH3, C2H5): a combined vibrational spectroscopic and ab initio study.
69. Fausto, R., Teixeira-Dias, J.J.C., Tonge, P.J. and Carey, P.R. (1994) J. Mol. Struct. 324, 113-122. Rotational isomers of N-(b -phenylpropionyl)alanine ethyl dithioester: a Raman spectroscopic and MO study.
70. Fausto, R., Martins, A.G., Teixeira-Dias, J.J.C., Tonge, P.J. and Carey, P.R. (1994) J. Mol. Struct. 323, 59-69. Rotational isomerism in CH3C(=S)SCH3 and CH3(C=S)SC2H5: a combined vibrational spectroscopic and ab initio study.
1993
71. Tonge, P.J., Carey, P.R., Callender, R., Deng, H., Ekiel, I. and Muhandiram, D.D. (1993) J. Am. Chem. Soc. 115, 8757-8762. Characterization of trans and cis-5-methylthienylacryloylchymotrypsin using Raman difference spectroscopy, NMR and kinetics: Carbonyl environment and reactivity.
72. Tonge, P.J. and Carey, P.R. (1993) Advances in Spectroscopy 20, 129-161. Biomolecular Spectroscopy Part A, ed. Clark, R.J.H. and Hester, R.E. Raman, resonance Raman and FTIR spectroscopic studies of enzyme-substrate complexes.
73. Curtis, R.D., Tonge, P.J., Smith, I.C.P. and Jarrell, H.C. (1993) J. Magn. Reson. 102A, 110-113. DePakeing of dipolar-chemical shift NMR spectra.
1992
74. Tonge, P.J, and Carey, P.R. (1992) Biochemistry 31, 9122-9125. Forces, bond lengths and reactivity; fundamental insight into the mechanism of enzyme catalysis.
75. Tonge, P.J., Carey, P.R. and Anderson V.E. (1992) J. Am. Chem. Soc. 114, 8738-8739. Multiple forms of acetyldithio-coenzyme A binding to citrate synthase; resonance Raman evidence.
76. Tonge, P.J., Gour-Salin, B., Lachance, P., Storer, A.C. and Carey, P.R. (1992) Biophys. J. 63, 191-196. Resonance Raman spectroscopic and kinetic consequences of a nitrogen-sulphur enzyme-substrate contact in a series of dithioacylpapains.
1991
77. Tonge, P.J., Pusztai, M., White, A.J., Wharton, C.W. and Carey, P.R. (1991) Biochemistry 30, 4790-4795. Resonance Raman and FTIR spectroscopic studies of the acyl carbonyl group in [3-(5-Methyl-2-thienyl)acryloyl]-chymotrypsin: evidence for artifacts in the spectra obtained by both techniques.
78. Tonge, P.J., Menard, R., Storer, A.C., Ruzsicska, B.P. and Carey, P.R. (1991) J. Am. Chem. Soc. 113, 4297-4303. Markedly different acyl-papain structures deacylate at similar rates: Resonance Raman spectroscopic and kinetic evidence.
1990
79. Tonge, P.J. and Carey, P.R. (1990) Biochemistry 29, 10723-10727. Length of the acyl carbonyl bond in acyl-serine proteases correlates with reactivity.
80. Carey, P.R. and Tonge. P.J. (1990) Chem. Soc. Rev. 19, 97-120. Chemistry of enzyme-substrate complexes revealed by resonance Raman spectroscopy.
1989
81. Tonge, P.J. and Carey, P.R. (1989) Biochemistry 28, 6701-6709. Direct observation of the titration of substrate carbonyl groups in the active site of a-chymotrypsin by resonance Raman spectroscopy.
82. Tonge, P.J., Lee, H., Sans Cartier, L.R., Ruzsicska, B.P. and Carey, P.R. (1989) J. Am. Chem. Soc. 111, 1496-1497. Striking changes observed in key acyl-enzyme linkages by resonance Raman experiments near 77 K.
83. Sans Cartier, L.R., Tonge, P.J. and Carey, P.R. (1989) Indian Journal of Physics. 63, 5170-5179. Resonance Raman studies of enzyme-substrate intermediates at cryogenic temperatures: construction of a cryostat-based U.V. resonance Raman system.
84. Tonge, P.J. and Carey, P.R. (1989) J. Mol. Liquids. 42, 195-212. Resonance Raman and absorption spectroscopic characterization of the chemically engineered enzyme thiolsubtilisin: comparison with a natural thiolenzyme.
85. Tonge, P.J., Moore, G.R. and Wharton, C.W. (1989) Biochem. J. 258, 599-605. Fourier-Transform infra-red studies of the alkaline isomerization of mitochondrial cytochrome c and the ionization of carboxylic acids.
1985
86. Tonge, P.J. and Wharton, C.W. (1985) Biochem. Soc. Trans. 13, 929-930. Observation of carbonyl stretch vibrations in acyl-chymotrypsins by using Fourier-Transform infra-red spectroscopy.
87. Tonge, P.J., Wharton, C.W., Szawelski, R.J., Killough, P.M. and Hester, R.E. (1985) Biochem. Soc. Trans. 13, 930-931. Ultra-violet resonance Raman spectroscopy of a highly specific acyl-papain.